Stanford Medicine Professor John Ioannidis caused quite a stir a few years ago with a paper in PLOS Medicine entitled “Why Most Published Research Findings are False” (according to PLOS, the paper has been accessed more than a million times). Now, Ioannidis returns to the (electronic) pages of PLOS Medicine, and switches from despair to action with “How to Make More Published Research True”:

“The achievements of scientific research are amazing. Science has grown from the occupation of a few dilettanti into a vibrant global industry with more than 15,000,000 people authoring more than 25,000,000 scientific papers in 1996–2011 alone [1]. However, true and readily applicable major discoveries are far fewer. (…) We need effective interventions to improve the credibility and efficiency of scientific investigation.”